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Ebola vaccine trial to begin in DR Congo amid 'exponential' spread

A trial of the Ervebo vaccine is set to start in the Democratic Republic of Congo to test its effectiveness against the Bundibugyo species of Ebola, as the World Health Organization warns of rapid infection growth.

  • The Ervebo vaccine is being trialled against the Bundibugyo species of Ebola, for which there are currently no proven vaccines or treatments.
  • The WHO states that Ebola is "growing exponentially" in northern and eastern DR Congo, with half of the nearly 2,500 deaths occurring in the last 20 days.
  • Rebel group M23 has imposed new travel restrictions in North Kivu province following reports of two Ebola cases in an M23-controlled village.

The Democratic Republic of Congo is preparing to launch a trial for an Ebola vaccine, using some doses to assess its effectiveness against the Bundibugyo species of the virus. While the Ervebo vaccine protects against the Zaïre species of Ebola, there are currently no proven vaccines or treatments for Bundibugyo.

This rollout comes as the World Health Organization (WHO) issued a warning that Ebola is "growing exponentially" in the north and east of DR Congo. The WHO's Ebola co-ordinator, Julien Harneis, stated that the spread of infections now covers an area larger than France. Close to 2,500 people have died in this outbreak, which began three months ago, with half of these deaths occurring in the last 20 days.

The WHO confirmed that 20,000 doses of the Ervebo vaccine will be used in a clinical trial to evaluate its effectiveness against Bundibugyo. Additionally, 50,000 doses will be given to front-line health workers. Experts suggest the Bundibugyo species may have been circulating since February, initially misdiagnosed as typhoid and malaria.

Meanwhile, the M23 rebel group, which controls parts of eastern DR Congo, has announced new restrictions on movement between government and rebel-held areas of North Kivu province. Shared taxis and passenger boats will be suspended for one month starting on Saturday. These measures follow reports of two travellers testing positive for Ebola in an M23-controlled village.

Why this matters: The rapid spread of Ebola, particularly the Bundibugyo species for which there is no proven vaccine, poses a significant public health challenge in DR Congo. The ongoing conflict further complicates efforts to control the outbreak.

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