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Merseyside woman first globally to receive new lung cancer vaccine

A woman from Merseyside has become the first patient worldwide to receive a new vaccine in a clinical trial for advanced lung cancer. Doctors hope the vaccine could significantly improve treatment for some forms of the disease.

  • The vaccine uses cells from the patient's own tumour to create synthetic DNA.
  • It is hoped the vaccine will make immunotherapy more effective for patients whose cancer has become resistant.
  • Only 10 people will participate in this early stage trial, receiving seven doses over 24 weeks.

Chris Jones, 68, from Hoylake, Wirral, is taking part in a new clinical trial at the Clatterbridge Cancer Centre in Liverpool. She has advanced non-small cell lung cancer, which accounts for over 80% of all lung cancers.

The experimental vaccine is designed using cells from Ms Jones's own tumour to create synthetic DNA. This process aims to boost the immune system and make immunotherapy more effective, particularly for patients whose cancer has developed resistance.

Medical Oncology Consultant Dr Carles Escriu noted that about half of patients treated with immunotherapy experience an initial response but their cancer eventually becomes resistant. The trial aims to achieve a long-term response in such cases.

Ms Jones will receive seven doses over the next 24 weeks. Researchers hope this early stage trial will improve care for more than half of patients with advanced lung cancer.

Why this matters: This early stage clinical trial represents a potential new approach to treating advanced lung cancer, particularly for patients whose cancer has become resistant to existing immunotherapy.

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